5/1/2025
Last update
5/1/2025
Research Authors
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 48 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
Top Medical Research Studies
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Most Useful Reviews
10
Daily relief
4 people found this helpful
I ordered this probiotic due to stool issues. To my surprise, it worked wonders! My bathroom habits became regular, and I would recommend it to anyone facing a similar problem.
9
Sensitive digestion
2 people found this helpful
This product is magnificent and works effectively. I'm addicted and ordering again due to the high quality and good packaging that keeps it fresh. I truly feel the difference when taking this supplement compared to when I don't. It suits my sensitive digestive system very well, and absorption seems excellent. I warmly recommend it.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 48 Researches
8
- All Researches
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Daily relief
4 people found this helpful
I ordered this probiotic due to stool issues. To my surprise, it worked wonders! My bathroom habits became regular, and I would recommend it to anyone facing a similar problem.
9
Sensitive digestion
2 people found this helpful
This product is magnificent and works effectively. I'm addicted and ordering again due to the high quality and good packaging that keeps it fresh. I truly feel the difference when taking this supplement compared to when I don't. It suits my sensitive digestive system very well, and absorption seems excellent. I warmly recommend it.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
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